Team: PD Dr. M. May, Dr. M. Brand, PD Dr. W. Wüst, Dr. S. Ellmann, Prof. Dr. M. Uder
Radiation-induced DNA double strand fractures (DSB) can be determined by immunofluorescence microscopy. Studies in patients showed a strong correlation of DSB in blood lymphocytes with the deposited dose. On the other hand, the exact dose distribution in the human body can be assessed individually using mathematical Monte Carlo simulations. Findings learned using these methods are used to optimize the radiation dose and image quality. Studies evaluate modern technical methods for modulating the X-ray spectrum, shortening the duration of the examination, calculating images, and processing images for clinical use. In addition, the potentially protective effect of radical binding substances on DSB induction in vivo and in vitro is evaluated.