Cardiac CT and MRI are rapidly evolving techniques with high demands on technology, technician and physician. Speed, workflow and systematic analysis are crucial aspects of CT examinations of the heart in adults and children. In cardiac MRI quantitative myocardial T1- and T2-mapping methods and the introduction of accelerated acquisition techniques represent two of the most important developments within the last years. Research and clinical application of cardiac imaging techniques are performed in close relationship with the Department of Cardiology.
Mapping native T1-, T2- and T2*-relaxation times has emerged as a promising tool to assess pathologies diffusely affecting the myocardium. However, the implementation of cardiac mapping technologies into routine clinical decision-making is still limited by significant inter- and intraindividual variability of relaxation times. The reproducibility of mapping values is affected by scanner hardware, acquisition software and subject-related factors. Our study group focussed on the impact of the scanner system on myocardial T1-, T2- and T2*- relaxation times by assessing the robustness and homogeneity of myocardial mapping results in healthy volunteers in three identical 1.5T CMR systems in order to investigate the interscanner reproducibility.
Compressed sensing is considered as a modern key technology in accelerating MR data acquisition. In cardiac imaging a wide variety of application examples is currently under investigation. Our group applied compressed sensing in complete free-breathing adenosine stress cardiac MRI and in high-resolution 3D water-fat Dixon LGE imaging.
In cooperation with the Department of Nephrology and Hypertensiology our group is participating in a variety of international multicenter studies on radiofrequency, ultrasound and alcohol mediated renal denervation techniques in treating hypertension (e.g. Spyral HTN On-Med study, Spyral HTN Off-Med study, Spyral distal study, Radiance II study, Peregrine Post-Market Study).
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